1.used to describe a strain of cannabis that leaves you feeling alert.
2. A street term that refers to any prescription or non-prescription substance that is a stimulant. Leaves the user feeling hyper and sometimes anxious.

"You got any uppers?"
by Luna29 on 07/27/2017

A Sativa or Sativa Dominate strain that will keep you alert and focused on surroundings. Not to a paranoid level though.

Wow, that Grapefruit is a real Upper, had me on the go go go...
by Raphaelia James on 04/18/2018